1 In roughly 20% to 30per cent of situations of postmenopausal genital bleeding, the main cause can be caused by endometrial cancer tumors or atypical endometrial hyperplasia. 2 Additional factors consist of estrogen or progesterone treatment (for example., hormones replacement therapy HRT) and vaginal atrophy because of low estrogen amounts. 2 Age and menstrual status influences the explanation for irregular vaginal bleeding; in postmenopausal females, structural problems are normal underlying factors (TABLE 1). 3 Although postmenopausal genital bleeding continues to be a cardinal manifestation of endometrial cancer tumors, instance reports show it might be a unique presenting indication of other diseases as fine, including non-Hodgkin lymphoma and pancreatic adenocarcinoma. 4,5